Hi
@Shakermaker.
I asked perplexity ai to summarise the 'mechanism' of what can be going on when the cause is mind-body/TMS, as follows:
"When you have persistent pain in your hamstring and/or shoulder with only "mild inflammation" and no tears or ruptures present, it is easy to assume that the inflammation is the direct cause of your pain. However, modern neuroscience reveals a very different, encouraging reality: your body isn't structurally broken; your nervous system has just gotten stuck in an overprotective "false alarm" loop.
While older theories suggested this was caused by restricted blood flow or structural damage, modern science shows it is actually a nervous system glitch called Neuroplastic Pain.
More about this:
- Mild Inflammation Can Be Completely Pain-Free: Large-scale medical studies show that a huge percentage of people without any pain have mild inflammation, small tears, or wear-and-tear in their tendons. Under normal circumstances, mild inflammation sits well below your "pain threshold" and goes entirely unnoticed while the body naturally maintains it.
- So, What Actually Causes the Inflammation? If there is no physical tear, the mild inflammation is likely being caused by Neurogenic Inflammation—meaning it is generated by the nervous system, not by mechanical injury. When your brain stays in a chronic "fight-or-flight" state due to stress, pressure, or anxiety, it sends continuous distress signals down your nerve pathways. These overactive nerves release chemical messengers (like Substance P) directly into your shoulder and hamstring tissues. These chemicals cause local blood vessels to leak a tiny amount of fluid, creating a real, physical state of mild inflammation—but it was switched on by a stressed brain, not by a physical strain.
- The Hyper-Sensitive Volume Knob (Central Sensitization): Because your nervous system is in this high-alert state, it turns the "volume dial" on your body's sensory inputs all the way up. Suddenly, the tiny amount of neurogenic inflammation that a calm nervous system would easily ignore is magnified by the brain into intense, debilitating pain.
- "Inverted Healing": If you had a minor injury in the past, the tissue has done its job to repair. However, your brain memorized the pain pathway. Now, normal movements trigger that old memory, and your brain uses the presence of that minor, nerve-driven inflammation as "proof" that it needs to keep screaming at you with pain.
The Bottom Line: The mild inflammation is a real physical finding, but it is not a sign of structural failure. It is the physical footprint of a hyperactive nervous system that has forgotten how to switch off its alarm. Because this is a neurological loop rather than a structural injury, it can be retrained and reversed."
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And the following is from
https://cbphysiotherapy.com.au/the-correlation-between-imaging-and-symptoms-in-tendinopathy/ (Imaging & Tendinopathy Symptoms | CB Physiotherapy)
"THE CORRELATION BETWEEN IMAGING AND SYMPTOMS IN TENDINOPATHY
Imaging results (x-ray, MRI, CT and ultrasound) in general correlate very poorly with an individual’s reported symptoms. Tendinopathy is a great example of this.
A pathological tendon found on imaging (with an MRI/US reporting tendinosis, degeneration, disorganization of fibres or intratendinous tears) is purely a RISK FACTOR for a painful tendon, rather than a definitive diagnosis. These findings will make you 3-15x more likely to have a painful tendon (or clinically a tendinopathy).
Think of it like smoking and lung cancer. Smokers are far more likely to have lung cancer than non-smokers, but it is not guaranteed. Just like people with degenerative tendons on imaging reports are simply more likely to have a tendinopathy.
We know that there is a very high prevalence of asymptomatic tendon pathology found on imaging (up to 50% in some groups). This means that almost half of people with a crappy looking MRI or ultrasound will have no pain!
We need to focus on pain and function, not on imaging reports…
Chris Bryceson B. Health Sciences (Physio), APAM CB Physiotherapy"
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