Hi there. While I don’t doubt there is a TMS component of RLS, RLS has been found to be the result of low serum ferritin in the brain for many patients. This is different than lack of iron in the blood, such as anemia. The U.S. RLS Foundation recommends Ferritin levels be at least 150 before ruling out this cause. This is 3-4 times higher than the standard for anemia. The only way to get to this level is with intravenous iron infusion. Oral iron pills will not bring up levels to this number, even though this number is safe (even up to 300 is safe for adults). Oral iron actually causes ferritin levels to decrease after a fairly short period of time- the body’s way of preventing levels from getting too high: a great mechanism for non RLS patients but a frustrating situation for RLS patients. IV iron infusion is the solution for getting around this. You’ll find the research for this as well as a list of approved specialists, ferritin testing testing instructions (don’t take the blood test during an infection, after taking iron pills or on a full stomach, after a meat-heavy meal the night before, etc.), and infusion guidelines on the RLS Foundation’s website and YouTube channel.