We may experience stress, anxiety, fear, sadness, and loneliness as a result of the COVID-19 pandemic. Mental illnesses, such as anxiety and depression, can deteriorate. When compared to surveys conducted prior to the pandemic, surveys show a significant increase in the number of U.S. adults reporting symptoms of stress, anxiety, and depression during the pandemic. Some people have increased their alcohol or drug consumption in the hopes of coping with their fears about the pandemic. In reality, these drugs can exacerbate anxiety and depression. If people with substance use disorders get COVID-19, their outcomes are likely to be worse, especially if they are addicted to tobacco or opioids. This is because these addictions can impair lung function and weaken the immune system, leading to chronic diseases like heart disease and lung disease, which raise the risk of serious COVID-19 complications.