In our thread about Neurasthenia/Chronic Fatigue Syndrome (ie TMS), @BruceMC wrote, A couple of days ago, I was struck by a radio report about anxiety and depression among people working at tech startups in Boston: You can listen to the story here: startup anxiety. They had Dana Severson as a guest. Here's his story, from an article in The Atlantic entitled, "Tech Has A Depression Problem:" You can read the entire article here: Tech has a Depression Problem. Both stories really grabbed me because I could relate to the ups and downs of running a startup. Will what you create keep growing for the rest of your life or will it be gone in five years? Acceptance is an amazing tool for mental healthy, but when there is that much uncertainty, you can't become "well adjusted." What do you adjust to? The good outcome or the bad? Life can be a rollercoaster, depending on which you think will happen. In a startup, you have to do a million things that you've never had to do before, and the pressure can be intense, because it could either be the biggest success of your life or a complete failure, and you don't know which. Hence the rollercoaster.