What was the most disheartening thing a doctor has told you about your symptoms? The news I was tested positive for HLAB27, I was told AS is incurable, to go home and read on NSAID, MTX and Biologic. I almost fainted on the spot. In what ways have you kept that in your mind? Initially, I was emotionally devastated, always crying, asking myself why I was born with the gene (why me???), and very fearful about my future. How was I as a daughter to my parents, whose bones were going to grow old and brittle faster than my parents'? How was I going to have children and so on ... ? All these kept on replaying in my waking mind daily, I felt like going mad coupled together with aching and pain which moved here and there.