This question was submitted via our Ask a TMS Therapist program. To submit your question, click here. Question Do endorphins play a significant role in long-term recovery from PPD? The reason I ask is because my pain only seems to improve when I'm in an unusually good mood, and I assume this is because of the pain-negating effects of endorphins. Obviously it's impossible to be in a fantastic mood all or even most of the time, so depending on endorphins for relief doesn't seem like a viable strategy for recovery. Or is it? Part 2 - am I correct to view the pronounced effect of mood on my pain level as strong evidence of PPD? This may seem like a no-brainer, but the reason I ask is because I assume that pain due to a structural cause would also behave this way. I would love any insight here. Thanks and sorry for being a bit long-winded!