Hi Boston,
When I first learned about TMS (over 18 months ago), I was taking the maximum dose of tramadol every day for chronic pain, and had been on it for 15 years. I was also taking a beta blocker every day to prevent migraines, and had been on it for 18 years. Neither medication worked--I still had pain and frequent migraines. So once I started treating my pain as TMS and started having periods of no pain or reduced pain, I decided to wean myself off the tramadol. I did it very slowly, but still had withdrawal symptoms that took awhile to completely get over. Once I was over the tramadol, I began to wean myself off of the beta blocker, and again, I had some symptoms during the process, but I finally got through it. It was difficult, but I'm glad I did it. I've been mostly pain free and migraine free since, though I do have an occasional relapse.
I still take an antidepressant and have for half my life. I've started weaning myself off of it slowly. I am now taking 2/3 of the dose I was on. I know from reading Schubiner's book on anxiety and depression that I can expect to have some rebound depression when coming off antidepressants, so I will take it very slow.
Not everyone has withdrawal symptoms when they stop taking a medication or reduce the dose. I had been taking mine for a long time and my brain was very used to them.
Everyone has to make their own decisions about taking medications---when to do it and when to stop. You have to weigh the risks and benefits. I wasn't getting any benefit from mine, and I had begun to see a difference in pain levels from using TMS strategies, so it was time for me to stop taking them.