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Duke Finds a Pain "Off" Switch in the Amygdala of Mice

Discussion in 'General Discussion Subforum' started by BruceMC, Aug 12, 2021.

  1. BruceMC

    BruceMC Beloved Grand Eagle

    https://today.duke.edu/2020/05/neurobiologist-finds-potent-pain-suppression-center-brain (Neurobiologist Finds Potent Pain-Suppression Center in the Brain)

    Interesting how the key to turning off pain resides in the same location in the brain where fight-flight-freeze response is also generated. Like they're interrelated.

    Found this study cited in the same Pain PT YouTube video that describes the role of fear in perpetuating chronic pain:

    This article is also cited in the same YouTube video:

    https://www.sciencedirect.com/science/article/pii/S0005796720300863 (Fear in the context of pain: Lessons learned from 100 years of fear conditioning research - ScienceDirect)
    TG957 and Cap'n Spanky like this.
  2. Cap'n Spanky

    Cap'n Spanky Well known member

    Really interesting stuff! "It’s also located in an area where few people would have thought to look for an anti-pain center, the amygdala, which is often considered the home of negative emotions and responses, like the fight or flight response and general anxiety."
  3. BruceMC

    BruceMC Beloved Grand Eagle

    Suggests to me that chronic pain patients were children that had extremely frightening and traumatic ACEs (adverse childhood events) during brain development before their 6th birthdays when the fright-flight-freeze mammalian survival response got triggered and frozen in their amygdala (two). I'd guess a subsequent traumatic event during their lives activated that same response again, producing chronic pain symptoms. Of course, I'm not a neuroscientist by any means and this is just my educated guess work. I'd think Jim at the Pain PT site would have more to say about this.
    Cap'n Spanky likes this.

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