Yes. Absolutely. I have RSI in both elbows, during the initial flare my elbow was noticeably puffy/inflamed. Plenty of success stories will,report swelling and other physical changes. The brain can create literally any sensation, and the subsequent immune response can create physiological changes.
It’s still wise to follow up with a doctor and get an x ray to make sure everything looks good, especially since you have hardware, but then you can proceed with treating as TMS.